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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: ITCH All Species: 6.06
Human Site: S236 Identified Species: 12.12
UniProt: Q96J02 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0.18
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q96J02 NP_113671.3 903 102803 S236 A G E N R R V S G N N S P S L
Chimpanzee Pan troglodytes XP_001135661 927 105765 E236 A P K P L A S E P A D D T V N
Rhesus Macaque Macaca mulatta XP_001083053 927 105532 E236 A P K P L T S E P A D D T V N
Dog Lupus familis XP_851460 862 98826 T236 V N G S P S A T S E S D G S S
Cat Felis silvestris
Mouse Mus musculus Q8C863 864 98975 N236 V N G S P S T N S D S D G S S
Rat Rattus norvegicus Q62940 887 102376 Q240 P D A A T H L Q H P P E P S P
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001506950 1107 125075 S419 P A P K P L T S Q P A T S T V
Chicken Gallus gallus XP_417330 878 99980 S236 G S V N G S P S T S T E N D G
Frog Xenopus laevis Q2TAS2 751 86306 G143 L Q S R D R I G S G G Q V V D
Zebra Danio Brachydanio rerio A9JRZ0 765 87445 N157 D C S R L F D N D L P D G W E
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9Y0H4 949 107948 S266 W E Q Q Q Q Q S Q N Q Q Q P L
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P39940 809 91798 T201 Q S G T T A A T N T A T T S H
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 59 59 93 N.A. 91.6 30.7 N.A. 49.2 78.1 35.8 36.2 N.A. 49.6 N.A. N.A. N.A.
Protein Similarity: 100 72.1 71.7 94.2 N.A. 93.6 47.9 N.A. 62.4 84.5 52.4 52 N.A. 64 N.A. N.A. N.A.
P-Site Identity: 100 6.6 6.6 6.6 N.A. 6.6 13.3 N.A. 6.6 13.3 6.6 0 N.A. 20 N.A. N.A. N.A.
P-Site Similarity: 100 20 20 26.6 N.A. 33.3 20 N.A. 26.6 20 13.3 6.6 N.A. 40 N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. 34.6 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 50.9 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 6.6 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 20 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 25 9 9 9 0 17 17 0 0 17 17 0 0 0 0 % A
% Cys: 0 9 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 9 9 0 0 9 0 9 0 9 9 17 42 0 9 9 % D
% Glu: 0 9 9 0 0 0 0 17 0 9 0 17 0 0 9 % E
% Phe: 0 0 0 0 0 9 0 0 0 0 0 0 0 0 0 % F
% Gly: 9 9 25 0 9 0 0 9 9 9 9 0 25 0 9 % G
% His: 0 0 0 0 0 9 0 0 9 0 0 0 0 0 9 % H
% Ile: 0 0 0 0 0 0 9 0 0 0 0 0 0 0 0 % I
% Lys: 0 0 17 9 0 0 0 0 0 0 0 0 0 0 0 % K
% Leu: 9 0 0 0 25 9 9 0 0 9 0 0 0 0 17 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 17 0 17 0 0 0 17 9 17 9 0 9 0 17 % N
% Pro: 17 17 9 17 25 0 9 0 17 17 17 0 17 9 9 % P
% Gln: 9 9 9 9 9 9 9 9 17 0 9 17 9 0 0 % Q
% Arg: 0 0 0 17 9 17 0 0 0 0 0 0 0 0 0 % R
% Ser: 0 17 17 17 0 25 17 34 25 9 17 9 9 42 17 % S
% Thr: 0 0 0 9 17 9 17 17 9 9 9 17 25 9 0 % T
% Val: 17 0 9 0 0 0 9 0 0 0 0 0 9 25 9 % V
% Trp: 9 0 0 0 0 0 0 0 0 0 0 0 0 9 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _